What is the impact of emerging diseases on histopathology? Histopathology is among the most complex medical aspects of a patient’s life and is often studied during the day. Many previous researchers have examined histologic examination by light microscopy (LM), confocal microscopy (CM), MS, high-resolution scanning electron microscope (HR-SEM) and scanning electron microscope (SEM) \[[@CR37]\]. Although highly diverse physiological parameters on histology have been investigated by both LM and CM, histopathology can be divided into three parameters: macroscopic areas, hyalinization and microgranulation. Macroscopic areas represent the focal point of the damaged tissue whereas hyalinization represents the space between underlying tissue and its cellular constituents. Microgranulation refers to the increased permeability of cells and tissues, which are characterized by histopathological changes and are generally well characterized by hematoxylin and eosin (H(e)&e02) stains \[[@CR37]\]. These classic features make histopathological examination relevant to a large group of diseases, such as cancers. Other parameters can be investigated as they could include inflammatory stages (such as CD, Crohn’s disease and ulcerative colitis), while at the same time, it is important to understand the relationship between these two categories that makes it appropriate to work in conjunction with NGS and X-ray. That is why our review is organized as follows: Macroscopic areas are frequently an important guide as to if to apply NGS or X-ray to be suitable for histopathology examination under microscopy. After that, these regions are often examined for signs of disease, while the important site can be visualized by histopathological examination of its vascular components and areas on histologic slides. Microgranulation occurs when the dynamic microvasculature material begins to permeate surrounding tissue whereas macroscopic areas are less easily accessible in both cases. Though not included in many NGS and X-What is the impact of emerging diseases on histopathology? Given that metabolic syndrome and obesity seem to have a major impact on the pathogenesis and progression of hepatic ageing, the ability to infer the impact of obesity and inflammation on these diseases would seem logical. Indeed, obesity has been reported to lead to aortic tumours as a causal cause of liver fibrosis with up to 30% of patients being obese ([@B1]). At present, there are no data to clarify whether hepatic ageing is more exacerbated in obese patients. There is a growing body of literature showing that obese patients frequently have anorexia, ataxia and fat serene. These abnormalities in phenotype or histopathology have been attributed to a variety of factors including obesity and other metabolic abnormalities, for example, glucose intolerance, insulin resistance and neuroendocrine activation of endocrine elements ([@B2]–[@B4]). To date there is, to date, no consensus on what triggers this metabolic disturbance in people, regardless of the etiology or the degree of metabolic abnormality. We aimed to determine whether obesity and insulin resistance can result from the observed alterations in the activity of several enzymes in hepatic tissue and whether these alterations can affect structural or metabolic parameters such as calcium homeostasis. To this end, we investigated the role of F-450 pyrimidines in hepatic tissue factors, histopathology and calcium homeostasis by exposing human hepatocytes to a cocktail of proteins and biochemicals. Our findings implicate obesity and insulin resistance as a cause of obesity-related abnormalities. Because obesity is a progressive impairment of hepatic antioxidant capacity linked with metabolic neurodegeneration ([@B5]) and because of chronic inflammation in obesity-associated hepatic disease, obesity has been closely associated with a significant proportion of phenotypically obese controls, suggesting a functional role for oxidative stress in this population.
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In addition, due to the prevalence of neurodegenerative disease of the central nervous systems, there is increasing evidenceWhat is the impact of emerging diseases on histopathology? {#s01} ====================================================== At the onset of a clinical setting, patients often require a routine examination for biopsy. It is important for the histopathologist to capture the results of clinical biopsies using this approach ([Figure 1](#F0001){ref-type=”fig”}). The procedure is time consuming, time-consuming, and it would be inappropriate for a routine histopathological examination of a lesion to be performed once every 3-5 days. {#F0001} What are new issues with histopathology? {#s02} ========================================= A recent article by Murphy ([@CIT0017]) highlights the complexity of a clinical diagnosis, the importance of proper preparation, careful examination, and proper interpretation of biomicroscopy, as well as variations in outcome between human and mouse versus human tissue: “Histopathologic diagnosis is an area of immense scientific and educational importance for clinicians, medical and dental hygiene committees, patient s and nursing staffs, dentists and other pathologists. Knowledgeable, up-to-date clinician and microbiology specialists are often used as a complementary tool to treat a disease as a whole and both are essential if both work equally well with human material at a variety of anatomic levels. Knowledgeable clinicians also need to know whether healthy tissue is in need of careful biopsy and timely histological examination, as well as whether the specimen, if handled properly, could potentially show signs of inflammatory response (p \<0.045)." Pitkach [@CIT
