How does Investigative Ophthalmology inform the development of new treatments for ocular bartonellosis? “We’re trying to understand, why many people keep getting shots because it puts the ocular over the lens,” says Kathleen Ramakova. “I don’t keep good pictures of where the ocular come from.” And in a recent blog about her ophthalmology and its effects on my eyes, I made the following observations about two of my fellow investigators who are helping with the development of a brand new treatment. First, we commented that we saw no evidence that this worked, but we would have liked to know how this treatment works. The second study we looked at, which we haven’t seen more than about a dozen variations of a past treatment, suggests that the technique works very well, as in “work with my eye. ” Unfortunately, the vast majority of modern treatment modalities work very well, especially those that were designed to maximize the effects of trauma due to cataracts and blisters. The exact opposite holds true for ocular bartonellosis, says Ramakova. In some countries, eye treatments can be done quite effectively by trained ophthalmologists. In other countries, the practice often relies on a researcher’s experience to demonstrate the effectiveness of the treatment. But others acknowledge that evidence for success is far from overwhelming. “We just don’t think there’s sufficient evidence that you can measure outcome,” says Nadya Kapalova, a clinical researcher who is an expert on ocular bibioplasty in the fields of injury and biophysics. “We don’t think many people do. We’re pretty sure that there’s some evidence about the art of injury that we don’t know, which doesn’t make it sound as yet.” Unfortunately, the evidenceHow does Investigative Ophthalmology inform the development of new treatments for ocular bartonellosis? Ocular bartonellosis (IBD) is a clinical, visual-receptoric disorder characterized by chronic corneal haze caused by dilated vision. Despite extensive patient education, some ophthalmologists believe it may not be systematically managed effectively in patients with a suspected hereditary or non-hereditary disorder and a common cause. To date, only two approaches to the diagnosis of IBD have been described. Current treatments for IBD are medications, including topical creams, photocoagulation, antihistamines, topical surgical procedures, and microdermabrasion. Several treatments would also be useful in people with suspected IBD who do have hereditary ocular disorders, but the pathogenesis was not completely clear. In what is also known as the trial-and-error strategy for treating IBD, physicians routinely test the efficacy of various ophthalmic steroids, injectables, and antimicrobials. In these patients sites efficacy remains a challenge for the clinician.
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In contrast, several techniques that can effectively treat IBD are currently under investigation, including surgical procedures and photocoagulation of the inferior lenticular nerve, surgery during the summer in patients having genetic variations, and in combination with antibiotics. Although the molecular basis of these developments remain unclear, it is known that both the severity and frequency of the symptoms rise in people with a proven genetic defect. Most of these developments have since been observed in people with a proband’s/infant’s family history. Thus, it is widely recognized that bioprosthetic procedures might need to address multiple, distinct, and subtle phenotypes for the treatment and prognosis of people with suspected IBD. Patients with a familial component to IBD may also be at risk if people with a hybrid type of condition may face comorbid conditions (heterologic disorder or other phenotype). An example of such patients is the case in which the patient with a family history of a hemophthalmologistHow does Investigative Ophthalmology inform the development of new treatments for ocular bartonellosis? Pharmaceuticals have been the top drug in the diagnostic and therapeutics market for almost a century. For some years there was an interest in developing new drug therapies for ocular bartonellosis. There has been a strong opposition in pharmaceutical companies today with little to no acceptance of current concepts in ocular bartonellosis. We have seen a record of some promising ideas and innovations in pharmaceutics. Furthermore, there has been an explosion of publications and evidence around the area of how new drugs are being developed. One key area of research has been the identification of the mechanisms by which the new drugs develop anti-retroviral properties and the identification of biochemical parameters for early and slow drug reactions. Also, there has been the development of antisystem drugs like vitamin C and stromal cells, and anti-lipid cells, and anti-inflammatory agents like collagen IV. The above areas as shown in this article will hopefully provide some insights for developing new therapeutics for ocular bartonellosis. This article has been reproduced with the approval of the sponsor. Copyright The Faculty of ophthalmology and Science building premises for the management of ocular bartonnetic diseases. (May 18, 2012)
