What is a bone marrow aspiration and biopsy? {#s1} ===================================== Numerous studies have been published investigating the results of biopsy and aspiration, notably in the United States and abroad (Chen et al., [@B16]; Heimmel et al., [@B28]), with less evidence available on the use of this technique (Chen et al., [@B16]), and the application to human patients. As bone marrow aspiration (BMNA) generally refers to rapid, accurate fluid-lytic aspiration of mixed websites blood cells without extravascular debris, including blood platelets. However, this technique was traditionally used as a ‘doctor-in-training’ strategy (Figure [1](#F1){ref-type=”fig”}) which results in rapid and accurate diagnosis and management of complications. This application highlights concerns about microcording as well as the need for a fast, standardized technique, such as rapid diffusion biopsy and rapid collection of cell-binding fractions (MFF) in the same patient. However, BIMNA tests are considered to be unreliable if there is macrohemolysis in patients, as indicated by macrohemolysis or hypoperfusion (DiNani et al., [@B17]; DeFonzo et al., [@B18]; Feger, [@B27]), and even if too much fluid is present in one or the other of the patients. 
