What is neuroendocrine disorder? (2010). The current debate in the western sciences is focused on the effects of the oestrogens in the female brain. While this is an web link that only started to dawn in the early 1960s, there are now many well-established studies linking testosterone and oestrogen metabolism and ischemia in this area to the brain, a feature that many patients treated with oestrogens find so reassuring. Based on the literature, we propose a number of different hypotheses concerning hormone abnormalities and oestrogenesis in both men and women who develop a neuroendocrine disorder after menopause. The proposed hypothesis 1: At an early stage of disease, the development of a neuroendocrine disease is associated with multiple functional abnormalities in the eye, skin, pancreas, and ventilator organs. The occurrence and progression of such symptoms include abnormalities in eye, skin, pancreas, ventilator respiratory system, ventricle \[[@B1]-[@B4]\]. Such abnormalities are not observed in primary malignant melanomas because only one-third of them show evidence of damage to the cholinergic and adrenergic pathways. In addition to related functional alterations to ischemia and oestrogenesis, other functional interactions of the eye and skin contributing to these abnormalities are to be identified, which are probably caused by tissue fibrosis promoted by reactive oxygen species, possibly caused by both hormones and ODs – and the local processes of oestrogens, which are associated with the development of the ocular and cardiovascular system. These correlations are illustrated in Figure [6](#F6){ref-type=”fig”}. 
