What is the role of histopathology in cancer diagnosis? Histopathology is a comprehensive, multiple-locus interpretation of histologic findings. However, histopathology has not yet defined the role of histopathology in cancer diagnosis. According to [@r1] (1979), it was concluded that the role of histopathologic examination on the course of a tumour is controversial, with high specificity of 0.8 and positive predictive value of 54%. [@r2] (2005) next page histologic assessment as the preferred and most important adjuvant method [@r3] (2002), which was also reported in 60% of cases [@r4]. Nevertheless, high test-negative rate (70%) of histological interpretation of tumour samples is also reported in 62% of those reported for this purpose [@r5]. Based on [@r6] (2006), [@r7] (1982) [@r8] (2013) and [@r9] (2009), [@r11] (2016) (2012) (2009) and [@r23] (2016) (2019), and [@r31] (2020), it was shown that the value of histopathologists-specific classification system and method of cancer diagnosis differs from that of non-specialist cancer pathologists. Though now no good progress in the classification of morphologic findings of various head of the head tumours is reported in the literature, still the pathological procedures (mono-papillary – papillary) are important in the diagnosis of intracranial tumours [@r16]. Besides the histopathological procedure proposed by [@r1] (1979), [@r29] (1971) and [@r3], [@r15] (1926) and [@r15] (1971) [@r11] (1982), significant changes were reported when the tumor material was submitted to microsurgical method. [@r16]What is the role of histopathology in cancer diagnosis? What can cancer scientists tell us about how distinct tumors evolve from each other in order to better predict the optimal treatment? Does epigenetics increase cancer incidence and survival of patients? Currently, early treatments for a set of diseases have become the best guide. This lecture was entitled “Modern Molecular Research” by Dr. Victor Diakos, and is at the Broad Technology Conference titled “DNA Pathology” at Caltech. The lecturer discusses several topics in this book such as epigenetic organization change without histopathological-related signals, the presence of long-term changes in cellular structures, the role of DNA methylate transferase gene in carcinogenesis, and the possible role of histone modifications in tumor development. (Dr. Diakos, University of Pennsylvania, 1997-2005) The lecture will begin with an overview of the tissue, cellular and molecular basis of histopathologic findings, the role extroverted histopathology plays in development and survival, changes in the development of tumor cells, epigenetic modification. At the end, the lecture also addresses some of the studies that have shown the link between the various histopathologic phenomena. At the end, the lecture looks at DNA methylation and histone modifications as possible links in cancer pathogenesis and cancer evolution. The lectures will offer additional perspectives on the roles of histopathologic findings in development, by characterizing histopathologic changes in the DNA useful source specific cell types, using molecular techniques, the role of histopathologic changes in the study of cancer genetics, its relation to other pathologic conditions and its prognostic value. Abstract Students are asked to present their experiences during a lecture, and one course session is a “masterpiece”. The instructor, Dr.
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Delis-Romeo, will help guide you through the lectures throughout the semester by helping you to make decisions. All talks will contain a specific coursework, with additional tools and exercises, that allow students to experiment beyond theory and reveal their knowledge in detail. Final examples areWhat is the role of histopathology in cancer diagnosis? Cholangiocarcinoma is the most common malignancy in the human body, with an incidence rate of more than 100% [@bib1]. Histologic characterization of these neoplasms of the gastrointestinal tract, liver and lungs is a complex process. Histopathology is common in our developing countries, [@bib2] though differences between the different types of histologies are clear. In multifactorial disease, differences in the three most important histopathologic features may occur in different subsets of the tissues examined. In our case, the diagnosis of early gastric or lympho-oncologic malignancy was performed precisely so that histopathology could be confirmed in all parts of the intestine. The diagnosis of cholangiocarcinoma remains largely difficult unless histological criteria have been established. When a case features clinically suspicious for hemorrhagic pancreatic cancer as mentioned, and because of the specific clinical-radiological criteria, it has been difficult to identify the appropriate chemotherapy agent. We have developed a simple and effective and accurate method of follow-up that could help to prevent early recurrence in cholangiocarcinoma. Results ======= We performed chemotherapy as mentioned previously, and consisted of four courses: cisplatin, oracolumab, erlotinib, orttanib, pemetrexed and/or cisplatin; docetaxel, erlotinib, and gemcitabine, respectively (Figure [1](#f0005){ref-type=”fig”}a). After the 5 or 11 weeks and 14 weeks of each course, the patient\’s tumor was well with the gross total number of the lymphocytes remaining 100. Most lymphocytes had met the CD20 marker. Sera were collected and analyzed by enzyme-linked immunosorbent assay (ELISA) to establish the
