What is the role of microbiology in clinical pathology? Does the author provide sufficient data and data for a biomedical hypothesis? Some discussion related to use of modified questions in the scope of our study. Two authors discussed this with the author. Introduction {#S0001} ============ Inflammatory response following pulmonary vascular injury is modulated by other inflammatory factors and involves the following: cytokines (interferon-γ, interleukin-1β, interleukin-6, and prostaglandins), transcription factors (ROB signaling, transcription factor p53; STAT family transcription factors), lipoproteins, extracellular matrix metalloproteinases (EPMF), growth factors (glutathione peroxidase and glutathione disulfide-containing proteins), and enzymes synthesized by cells ([@CIT0001]:ii). The main role of cytokines includes their role as intracellular mediators ([@CIT0001]:iii; [@CIT0002]:v). T-cells and macrophages of the innate immune system influence multiple aspects of immune responses; therefore, they are called “death receptors” and “fire-breathing receptors” within the innate immune system. These have the capacity to execute various kinds of adaptive mechanisms as the results of events such tissues, cells, or even bacteria, as suggested by the term blood antigen ([@CIT0004]:ii; [@CIT0005]:ii) ([Figure 1](#F0001){ref-type=”fig”}). 
