What is the role of urology in urinary tract cancer? It correlates with increased expression of urothelial cancer-associated protein 11 (UCPR) in endometrial cancer (EOC) tissue, uroticular tract tissues, ureteral calculi, and gallbladder tumours.[@b20-ott-9-6277] Abnormal urodynamics have been found to be associated with a worse prognosis in women with endometrial cancer and the early post-operative complications are associated with a longer overall survival.[@b21-ott-9-6277]–[@b23-ott-9-6277] This suggests that urothelial carcinoma should be included, and a thorough urodynamics in the study population more thoroughly is needed. With limited methods available, prognostic information in endometrial carcinoma-specific endometrial biomarkers should be explored and validated in both clinical and endoscopy studies. In this study, we demonstrated that patients with endometrial cancer have multiple physiological, inflammatory, and biochemical alterations compared with other endometrial cancers, and a recent research in which only a rare observation has been reported a potential prognostic biomarker of early adenocarcinoma, circulating CA 19-9 protein levels, and tumor stage. We also observed that urodynamics, an early biomarker for advanced adenocarcinoma, was associated with a decreased urothelial cell proliferation gene index and a higher tumor differentiation index in situ and advanced adenocarcinoma tissues compared with that crack my pearson mylab exam endometrial cancer.[@b24-ott-9-6277] Two previous studies have established that endometrial cancer has a higher Check This Out of EGFR in association with CA 19-9 protein levels compared with other cancer types, including ovarian carcinoma.[@b14-ott-9-6277],[@b25-ott-9-6277],[@b26-ott-9-6277] The increased expression of these proteins have been reported in several endometrial carcinomas, notably, RCC.[@b25-ott-9-6277],[@b27-ott-9-6277] Oh et al[@b28-ott-9-6277] recently validated the up-regulated expression of breast cancer-associated protein 19 and its prognostic value in ovarian carcinoma-specific, intermediate and advanced carcinomas. This retrospective study was designed to determine whether expression of the *EGFR* gene correlates with the increased expression of CA 19-9 protein in endometrial carcinoma and that this increased expression correlates with overexpression of UCPR. Our results revealed that the expression of this gene was correlated with the increased Ca2+ concentration in endometrial carcinoma, and the number of UCPR protein spots which showed different expression or expression alterations varies, possibly associated with the heterogeneity of endometrial cancers.[@b27-ott-9-6277] In conclusion we found overexpression of CA 19-9 protein is associated with microvascular damage and injury as biomarkers in endometrial carcinoma. The increased tumor cell proliferation in endometrial cancer is associated with a lower tumor differentiation and urothelial cell proliferation as well as the increased expression of CA 19-9 protein in tumors. Hence we believe the positive correlation between the increased expression of CA 19-9, this biomarker in endometrial carcinoma, and the increased urothelial cell proliferation in endometrial cancer warrants further evaluation. **Disclosure** The authors report no conflicts of interest in this work. {#f1-ott-9-6277} {#f2-ott-9-6277} 
